EDG-1 Polyclonal Antibody, 50ul[BT-AP02824] Antibody Humanization When translation ends upstream from

When translation ends upstream from the last exon-exon junction| this triggers NMD to degrade mRNAs containing premature stop codons

and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells

Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation

subunit:Homodimer or heterodimer (Potential)

EDG-1 Polyclonal Antibody, 50ul[BT-AP02824] Antibody Humanization When translation ends upstream fromThe sphingosine 1 phosphate receptor 1 encoded by S1PR1 is structurally similar to G protein coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine 1 phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell cell adhesion. Alternative splicing results in multiple transcript