Rb (Acetyl-K873/K874) Polyclonal Antibody, 50ul Pipette Filler This gene is the cellular

This gene is the cellular homolog of viral raf gene (v-raf)

Alternatively spliced transcript variants have been found for this locus

and it is mutated in a small subset of patients with Wilms tumor

There is a microRNA gene located within the 5' exon of this gene

Rb (Acetyl-K873/K874) Polyclonal Antibody, 50ul Pipette Filler This gene is the cellularThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.