NEDD4L Rabbit Polyclonal Antibody, 50ul Serological Pipets Alternative splicing of PIK3R1 results

Alternative splicing of PIK3R1 results in four transcript variants encoding different isoforms

The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue| the stratified epithelial lining of oral mucosa and esophagus| the outer root sheath of hair follicles| and the glandular epithelia

Phosphorylation on Ser-241 in the activation loop is required for full activity

Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends

NEDD4L Rabbit Polyclonal Antibody, 50ul Serological Pipets Alternative splicing of PIK3R1 resultsThis gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin conjugating enzymes to protein substrates thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial