Chk2(Phospho Thr68) Polyclonal Antibody, 50ul Monoclonal Antibody Preparation Alternative splicing and alternative promoter

Alternative splicing and alternative promoter usage results in multiple transcript variants

PDGFA encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF)

The large| uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain

The encoded protein plays an important role in maintaining stem cell populations| and may be aberrantly expressed in tumor cells

Chk2(Phospho Thr68) Polyclonal Antibody, 50ul Monoclonal Antibody Preparation Alternative splicing and alternative promoterIn response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the