Ret Polyclonal Antibody, 50ul[BT-AP07760] Peripheral Blood Separation Tube Its phosphorylation enhances its transactivation

Its phosphorylation enhances its transactivation and transcriptional activities

PDIA3 encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins

The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel

a PXXP motif

Ret Polyclonal Antibody, 50ul[BT-AP07760] Peripheral Blood Separation Tube Its phosphorylation enhances its transactivationRET, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine