ZNF295 Polyclonal Antibody, 50ul Site-directed Mutagenesis The 26 S proteasome may

The 26 S proteasome may be involved in trinucleotide repeat expansion| a phenomenon which is associated with many hereditary neurological diseases

Two alternatively spliced variants of this gene

acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases

which is thought to be associated with human longevity

ZNF295 Polyclonal Antibody, 50ul Site-directed Mutagenesis The 26 S proteasome mayZNF295 bears 8 C2H2 type zinc fingers and a BTB POZ (broad complex, tramtrack, bric a brac Pox virus and zinc finger) domain indicating a function in transcriptional regulation. ZNF295 has been shown to function as a transcriptional repressor and associates with ZFP161, a zinc finger protein also know to function as a repressor of transcription.