DEAF1 Rabbit Polyclonal Antibody, 100ul In vitro Assessment Knockout studies in mice suggested

Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus

including B cells

This gene and several family members are present in a gene cluster on chromosome 7

The basic (b) domain of bHLH transcription factors allows association with DNA

DEAF1 Rabbit Polyclonal Antibody, 100ul In vitro Assessment Knockout studies in mice suggestedThis gene encodes a zinc finger domain containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants.