IKK Gamma Polyclonal Antibody, 50ul[BT-AP04426] Site-directed Mutagenesis Contains 2 RING-type zinc fingers

Contains 2 RING-type zinc fingers

Mutations in this gene have been reported to be associated with nonsyndromic hearing loss

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle

the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity

IKK Gamma Polyclonal Antibody, 50ul[BT-AP04426] Site-directed Mutagenesis Contains 2 RING-type zinc fingersIKBKG encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.