ACSL3 Polyclonal Antibody, 20ul Serum PDGFRB is flanked on chromosome

PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor

The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes

but down regulated in ovarian cancer cell lines and primary carcinomas

Mutations in this gene have been linked with Li-Fraumeni syndrome

ACSL3 Polyclonal Antibody, 20ul Serum PDGFRB is flanked on chromosomeThe protein encoded by this gene is an isozyme of the long chain fatty acid coenzyme A ligase family. Although differing in substrate specificity subcellular localization and tissue distribution all isozymes of this family convert free long chain fatty acids into fatty acyl CoA esters and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain and preferentially utilizes myristate