EPAS-1 Polyclonal Antibody, 50ul Cell Labeling & Imaging A germline mutation of VHL

A germline mutation of VHL is the basis of familial inheritance of VHL syndrome

Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis

It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides

This gene is a member of the neuronal calcium sensor gene family| which encode calcium-binding proteins expressed predominantly in neurons

EPAS-1 Polyclonal Antibody, 50ul Cell Labeling & Imaging A germline mutation of VHLEPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The endothelial PAS domain protein 1 contains a basic helix loop helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.