Raf-1(Phospho Ser338) Polyclonal Antibody, 100ul Immune Repertoire Sequencing |PTM:The activation peptide is cleaved

|PTM:The activation peptide is cleaved by factor IXa (in the intrinsic pathway)| or by factor VIIa (in the extrinsic pathway)

Two pseudogenes of this gene have been identified on chromosomes 10 and 4

This encoded protein is a cell surface glycoprotein that is known to complex with integrins

The CARD domains of both proteins have been shown to specifically interact with BCL10| a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation

Raf-1(Phospho Ser338) Polyclonal Antibody, 100ul Immune Repertoire Sequencing |PTM:The activation peptide is cleavedThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.