CD23 Monoclonal Antibody(10H2), 20ul Drying & Desiccation 53BP1 activates the checkpoint kinase

53BP1 activates the checkpoint kinase ATM and promotes DNA double strand break repair via nonhomologous end joining (NHEJ) repair pathway

Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK

The autoimmune regulator plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus

This complex translocates to the nucleus and activates the transcription of interferons alpha and beta

CD23 Monoclonal Antibody(10H2), 20ul Drying & Desiccation 53BP1 activates the checkpoint kinaseThe protein encoded by this gene is a B cell specific antigen, and a low affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.