Flt-3(Phospho Tyr969) Polyclonal Antibody, 20ul Serum & Sample Tubes Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding distinct isoforms have been found for this GAP43

The encoded enzyme is a membrane-bound zinc-dependent metalloprotease

Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so

Multiple transcript variants encoding different isoforms have been found for NCBP2

Flt-3(Phospho Tyr969) Polyclonal Antibody, 20ul Serum & Sample Tubes Alternatively spliced transcript variants encodingThis gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis,