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It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids

A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis

There are two transcirpts variants in mRNA level

HTRA1 Polyclonal Antibody, 50ul Molecular Biologyn Experience ultimate precision and reliabilityThis gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin like growth factors (IGFs) by cleaving IGF binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age related macular degeneration type 7.