Canine Interleukin 33, IL-33 ELISA Kit, 96T Polyclonal Antibody Preparation The protein encoded by this

The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype

and its activity is mediated by adenylate cyclase

Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms

Was originally (PubMed:8327514) thought to be a high molecular weight interleukin (IL-14 or IL14)

Canine Interleukin 33, IL-33 ELISA Kit, 96T Polyclonal Antibody Preparation The protein encoded by thisCytokine that binds to and signals through the IL1RL1 ST2 receptor which in turn activates NF kappa B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T helper type 2 associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses