P53 Polyclonal Antibody, 50ul[BT-AP06811] Gel & Buffers Mice lacking this gene are

Mice lacking this gene are also hypersensitive to interferon| suggesting a function of this protein in downregulating interferon responses| independent of its isopeptidase activity towards ISG15

This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7

The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression

The MW of this protein is 50 kDa

P53 Polyclonal Antibody, 50ul[BT-AP06811] Gel & Buffers Mice lacking this gene areTP53 (tumor protein p53) encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni