Smad4 Polyclonal Antibody, 20ul Pathway and Network Analysis Specific mutations in DYSF have

Specific mutations in DYSF have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy

Kit includes choice of hydrogel with 12 x VitroPrime™® Cell Culture Inserts

which promotes calcium influx

Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107

Smad4 Polyclonal Antibody, 20ul Pathway and Network Analysis Specific mutations in DYSF haveSMAD4 encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine threonine receptor kinases in response to TGF beta signaling. The product of SMAD4 forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8 bp