TLR13 Polyclonal Antibody, 100ul NGS Oligos The formation of the GINS

The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al

which may indicate this protein has a role in origin activation

predominantly with 60S large ribosomal subunits

The ROS generated by family members have been implicated in numerous biological functions including host defense

TLR13 Polyclonal Antibody, 100ul NGS Oligos The formation of the GINSThe TLRs form a family of ligand binding proteins that engage a variety of microbial products, that on binding, activate signaling cascades leading to the synthesis of proinflammatory molecules. TLR13 is found in mouse and participates in the innate immune response to microbial agents. It acts via MYD88 and TRAF6, leading to NF kappa B activation, cytokine secretion and the inflammatory response.