Nibrin Polyclonal Antibody, 50ul[BT-AP06022] Immune Cell Analysis The protein encoded by this

The protein encoded by this gene represents the alpha subunit

The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK

|Contains 2 protein kinase domains

The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain

Nibrin Polyclonal Antibody, 50ul[BT-AP06022] Immune Cell Analysis The protein encoded by thisMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.