TFPI Polyclonal Antibody, 100ul Pipette Micro Tips Mutations in this gene have

Mutations in this gene have been associated with the Proteus syndrome

and a C-terminal PDZ domain-binding motif

is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation

GTP-binding proteins

TFPI Polyclonal Antibody, 100ul Pipette Micro Tips Mutations in this gene haveTFPI encodes a Kunitz type serine protease inhibitor that regulates the tissue factor (TF) dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa TF proteases in an autoregulatory loop.