Raf-1(Phospho Ser642) Polyclonal Antibody, 100ul Lysosome with variations due to deletions

with variations due to deletions

ERK2 and JNK

Reduced expression of this gene resulted in DNA replication defects| consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication

This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma

Raf-1(Phospho Ser642) Polyclonal Antibody, 100ul Lysosome with variations due to deletionsThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.