BEX2 Rabbit Polyclonal Antibody, 20ul Cell Senescence epigenetic silencing of SFRP genes

epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer

The gene encoding YTHDF1 maps to chromosome 20

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling

This gene has a partial pseudogene on chromosome 1

BEX2 Rabbit Polyclonal Antibody, 20ul Cell Senescence epigenetic silencing of SFRP genesThis gene belongs to the brain expressed X linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA binding complex that recognizes the E box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti proliferative effect