Tuberin Polyclonal Antibody, 50ul[BT-AP09285] Cellular Function Assays This receptor transduces signals that

This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK

There are two alternate translation start codons with this gene| which result in two forms of the protein

Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP)

The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade

Tuberin Polyclonal Antibody, 50ul[BT-AP09285] Cellular Function Assays This receptor transduces signals thatMutations in TSC2 (tuberous sclerosis 2) lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.