PDZK3 Polyclonal Antibody, 50ul Live Cell Imaging Knockout mouse studies show defects

Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures

possibly functioning in heterochromatin interactions

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade

and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa

PDZK3 Polyclonal Antibody, 50ul Live Cell Imaging Knockout mouse studies show defectsThe PDZ domain containing 2 encoded by PDZD2 contains six PDZ domains and shares sequence similarity with pro interleukin 16 (pro IL 16). Like pro IL 16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.