STEAP1 Polyclonal Antibody, 50ul Organelle Studies This protein has been identified

This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis

Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis|it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics)| abnormalities of brain development| and/or mental retardation of Down syndrome

The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes

MMP12 is part of a cluster of MMP genes on chromosome 11

STEAP1 Polyclonal Antibody, 50ul Organelle Studies This protein has been identifiedSTEAP1 is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell cell junctions.