Rb Polyclonal Antibody, 100ul[BT-AP07690] Microplate Mixer The protein localizes to cytoplasmic

The protein localizes to cytoplasmic filaments

Mutations in this gene are associated with nephronophthisis type 4

|subcellular location:Along actomyosin filaments and stress fibers

making it ideal for labs looking to increase throughput and save time

Rb Polyclonal Antibody, 100ul[BT-AP07690] Microplate Mixer The protein localizes to cytoplasmicThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.