SIR4 Polyclonal Antibody, 50ul Monoclonal Antibody Preparation Mutations in this gene cause

Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers

which are involved in a wide range of physiologic and developmental events (Ooe et al

Cyclin E1 accumulates at the G1-S phase boundary and is degraded as cells progress through S phase

Required for the actin rearrangement at cell-cell junctions

SIR4 Polyclonal Antibody, 50ul Monoclonal Antibody Preparation Mutations in this gene causeThis gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular