Human Pro-nerve Growth Factor, PRONGF ELISA Kit , 96T Lysosome This gene encodes a protein

This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase

Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed

A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis

When cloned

Human Pro-nerve Growth Factor, PRONGF ELISA Kit , 96T Lysosome This gene encodes a proteinNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed: 14976160, PubMed: 20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed: 20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and