ATP5G3 Polyclonal Antibody, 100ul In vitro Transcription A germline mutation of VHL

A germline mutation of VHL is the basis of familial inheritance of VHL syndrome

The coiled-coil motif is involved in homodimerization| the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity| and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes

Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis

The encoded protein may be involved in a wide range of biological processes including inflammation

ATP5G3 Polyclonal Antibody, 100ul In vitro Transcription A germline mutation of VHLATP5G3 (ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3) encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi subunit complexes: the soluble catalytic core, F1, and the membrane spanning component, Fo, comprising the proton channel.