KCNK4 (TRAAK) Polyclonal Antibody, 100ul Custom DNA Oligos They form a three-tiered signaling

They form a three-tiered signaling module composed of MAPKKKs| MAPKKs| and MAPKs

An important paralog of this gene is NEK2

A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2

Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons

KCNK4 (TRAAK) Polyclonal Antibody, 100ul Custom DNA Oligos They form a three-tiered signalingThis gene encodes a member of the TWIK related arachidonic acid stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia