Stat5a Polyclonal Antibody, 50ul[BT-AP08639] Polyclonal Antibody Preparation The protein encoded by this

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho| a protein involved in neurogenesis during embryonic development

and is specifically localized to epithelial cells in skin

are the main components of the nuclear pore complex in eukaryotic cells

interact with membrane-bound receptors

Stat5a Polyclonal Antibody, 50ul[BT-AP08639] Polyclonal Antibody Preparation The protein encoded by thisStat5 is activated in response to a wide variety of ligands including IL 2, GM CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL 3, which suggests its involvement in angiogenesis and cell motility.