MIB2 Polyclonal Antibody, 50ul Yeast Expression Also highly expressed in ovarian

Also highly expressed in ovarian and leukemia cell lines

In humans| this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes

The TRIM motif includes three zinc-binding domains| namely a RING| a B-box type 1 and a B-box type 2| and a coiled-coil region

calcification

MIB2 Polyclonal Antibody, 50ul Yeast Expression Also highly expressed in ovarianE3 ubiquitin protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction: Down regulated in many primary skin melanomas. Treatment with a demethylating agent, 5' aza 2 deoxycytidine, restores expression, suggesting that down regulation is the result