DBC-1 Polyclonal Antibody, 20ul Cell Culture Dishes Overexpression of PTK6 in mammary

Overexpression of PTK6 in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype

suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis

but not in other types of tumors

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DBC-1 Polyclonal Antibody, 20ul Cell Culture Dishes Overexpression of PTK6 in mammaryCore component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T) rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53 TP53