Erastin syl-L-homocysteine (SAH) Chemical Name: 6-[(2S

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Erastin syl-L-homocysteine (SAH) Chemical Name: 6-[(2SErastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i. e. HRAS, KRAS). Erastin produces non apoptotic tumor cell death by altering mitochondrial voltage dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized

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