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AZD-2281 - CAS# 763113-22-0 308 CAS Number: 1099644-42-4

AZD-2281 - CAS# 763113-22-0 308 CAS Number: 1099644-42-4

Name: AZD-2281 - CAS# 763113-22-0 308 CAS Number: 1099644-42-4
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AZD-2281 - CAS# 763113-22-0 308 CAS Number: 1099644-42-4AZD 2281, also known as Olaparib or KU 59436, CAS No. 763113 22 0, is a small molecule inhibitor of the nuclear enzyme poly(ADP ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. AZD 2281 selectively binds to and inhibits PARP, inhibiting PARP mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA damaging agents and may reverse tumor cell

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Description

CAS Number: 1099644-42-4

12 cells (EC50 ~261 nM) and H146 ALL cells (EC50 ~4

Formula: C30H29N5O6S2

It has ~125-fold greater selectivity over UCH-L1 (ubiquitin C-terminal hydrolase L1

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