SN-38 isoside F Exp Clin Endocrinol Diabetes

Exp Clin Endocrinol Diabetes

S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions

Smiles: OC(=O)C(F)(F)F

hydrolyzing long-chain fatty acid esters and thioesters) and promotes lipid storage in adipocytes

SN-38 isoside F Exp Clin Endocrinol DiabetesSN 38 is the active metabolite of irinotecan (an analog of camptothecin a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN 38 relative to irinotecan varies from 2 to 2000 fold. SN38 is metabolized via glucoronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of irinotecan predicts irinotecan toxicity, as it cannot be