SHP099 xHCl - SHP2 Phosphatase Inhibitor. CAS# 1801747-11-4 60305 1001264-89-6

1001264-89-6

SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells and counteracts Cyclopamine-KAAD inhibition of Smo

InChi: InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2

Guertin AD

SHP099 xHCl - SHP2 Phosphatase Inhibitor. CAS# 1801747-11-4 60305 1001264-89-6SHP099, CAS No. 1801747 11 4, is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0. 07 M and p ERK modulation in cells IC50 = 0. 250 M. SHP099 exhibits dose dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays