Gemcitabine (elaidate) KII-IN-1 CK-1827452 does not affect the
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Gemcitabine (elaidate) KII-IN-1 CK-1827452 does not affect theGemcitabine elaidate, also known as CO 101 and CP 4126, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di and tri phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide
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