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DDR1-IN-1 - CAS# 1449685-96-4 size:10mg solid PubMed PMID: 26933922

DDR1-IN-1 - CAS# 1449685-96-4 size:10mg solid PubMed PMID: 26933922

Name: DDR1-IN-1 - CAS# 1449685-96-4 size:10mg solid PubMed PMID: 26933922
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DDR1-IN-1 - CAS# 1449685-96-4 size:10mg solid PubMed PMID: 26933922DDR1 IN 1, CAS No. 1449685 96 4, is a potent and selective DDR1 inhibitor with IC50 of 105 nM, about 3 fold selectivity over DDR2. DDR1 IN 1 binds to DDR1 in the 'DFG out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1 IN 1 provides a useful pharmacological probe for DDR1 dependent signal transduction. The DDR1 receptor tyrosine

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Description

PubMed PMID: 26933922

22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3

Smiles: CC#CC(=O)N1CCC[C@H]1C1=NC(C2C=CC(=CC=2)C(=O)NC2=CC=CC=N2)=C2C(N)=NC=CN12

Molecular Weight: 412

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