Ranolazine dihydrochloride - CAS# 95635-56-6 xidant with anticancer activities Two general mechanisms for Dimesna

Two general mechanisms for Dimesna -mediated nephroprotection of cisplatin-induced nephrotoxicity involving the gamma-glutamyl transpeptidase (GGT)

6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3

InChiKey: QKUFZFLZBUSEHN-CZLJMHDISA-N

PMID: 29926593

Ranolazine dihydrochloride - CAS# 95635-56-6 xidant with anticancer activities Two general mechanisms for DimesnaRanolazine is an anti ischemic compound, which inhibits late sodium current that results in a reduction of Na+ dependent Ca2+ overload. Studies indicate that ATP production is shifted towards glucose oxidation by Ranolazine. This is due to the fact that more oxygen is required to phosphorylate the same amount of ATP during fatty acid oxidation than carbohydrate oxidation. These studies indicate that Ranolazine also inhibits oxygen consumption and