Diphylline ntin) PubMed Central PMCID: PMC4264672

PubMed Central PMCID: PMC4264672

FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth

171655-91-7

The pyridine regio-isomer GSK-J2 displays significantly less on-target activity (IC50 > 100 µM for human JmjD3) and thus can be used as control for target effects in vitro

Diphylline ntin) PubMed Central PMCID: PMC4264672Dyphylline is a phosphodiesterase inhibitor used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It also acts as an adenosine receptor antagonist. Dyphilline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other