ITD-1 - TGFβ inhibitor. CAS# 1099644-42-4 size:2mg solid MK-1775 was orally dosed to

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ITD-1 - TGFβ inhibitor. CAS# 1099644-42-4 size:2mg solid MK-1775 was orally dosed toITD 1, CAS No. 1099644 42 4, is a novel and highly selective TGF pathway inhibitor identified by a high throughput, embryonic stem cell (ESC) cardiac differentiation screening. ITD 1 promoted cardiomyocyte differentiation specifically via degradation of the TGF type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC50 0. 40. 8 M), revealing a role for TGF signaling

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