MK-1775 (AZD1775) - WEE1 Inhibitor. CAS# 955365-80-7 Catalog No.:M60299-2S Xcessbio is delighted to present

Xcessbio is delighted to present you compound libraries

InChi: InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5

GNF-2 dose-dependently inhibited the proliferation of osteoclast precursors through the suppression of the M-CSFR c-Fms

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids

MK-1775 (AZD1775) - WEE1 Inhibitor. CAS# 955365-80-7 Catalog No.:M60299-2S Xcessbio is delighted to presentMK 1775 (AZD1775), CAS No. 955365 80 7, is a highly potent, selective and orally bioavailable Wee1 kinase inhibitor with IC50 of 5. 2 nM. It abrogated DNA damaged checkpoints induced by gemcitabine, carboplatin, and cisplatin etc. and enhanced the anti tumor efficacy of these agents selectively in p53 deficient tumor cells. At tolerated doses, MK 1775 treatment leads to xenograft tumor growth inhibition or regression. It inhibits Wee1 in H3K36me3