BIX-02188 - CAS# 334949-59-6 Catalog No.:M60430-2S CAS Number: 1781835-13-9

CAS Number: 1781835-13-9

MERcK-5 delays the onset and reduced the magnitude of skin disease in an AD-like skin-disease model of NC/Nga mice

thus promoting LRP6 phosphorylation and Wnt signaling transduction

Chemical Name: ethyl 4-([1

BIX-02188 - CAS# 334949-59-6 Catalog No.:M60430-2S CAS Number: 1781835-13-9BIX 02188, CAS No. 334949 59 6, is a potent inhibitor of MEK5 (IC50 = 4. 3 nM) with reduced activity towards inhibition of ERK5 and TGFR1 (IC50s = 810 and 1, 800 nM, respectively). Inhibition of MEK5 by BIX 02188 induces apoptosis in cells expressing the oncogenic mutant FLT3 ITD. Product information CAS Number: 334949 59 6 Molecular Weight: 412. 48 Formula: C25H24N4O2 Chemical Name: (Z) 3 (((3 ((dimethylamino)methyl)phenyl)amino)(phenyl)methylene) 2